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The POLE gene provides instructions for making a protein that plays a very important role in repair of incorrectly copied DNA.  Mutations in this gene increase risk for colorectal cancer and often cause gastric and duodenal polyps as well as benign tumors.  According to NCCN guidelines, it is recommended that someone with this condition begins getting colonoscopies every two to three years between the ages of 25 and 30.  Additionally, if polyps are found, colonoscopies should be increased to every one to two years and surgical options should be considered.  This condition is inherited in an autosomal dominant manner, meaning each first degree relative (parent, child, and sibling) of an individual with this condition has a 50% chance of inheriting the disease causing mutation.