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MSH3 gene


Mutations in MSH3 often lead to increased polyps in the colon.  Although research is still ongoing, there is thought to be a high risk associated with colorectal cancer and mutations in MSH3. The National Comprehensive Cancer Network recommends that those with mutations in this gene get a colonoscopy every two to three years starting between the ages of 25-30.  If polyps are found, colonoscopy frequency should be increased to every one to two years.  If polyps become uncontrollable by colonoscopy, surgical measures should be considered.