RAD51D gene

RAD51D is a gene involved in the Fanconi anemia (FA)–BRCA pathway, which is critical for DNA repair by homologous recombination and interact in vivo with BRCA1 and/or BRCA2.  A person with a mutation in their RAD51D gene has an increased risk for breast and ovarian cancer over the course of their lifetime. Relative cancer risk is estimated at 1.32 and 6.3 respectively. This translates to nearly a 10% lifetime risk for ovarian cancer.