MEN1 gene

MEN1 - Multiple Endocrine Neoplasia Type 1

The MEN1 gene codes for a protein that acts as a tumor suppressor.  Mutations in this gene may cause Multiple Endocrine Neoplasia Type 1.   This syndrome causes tumors to develop in a person’s endocrine, or hormone producing, glands.  The pituitary gland, pancreas, and parathyroid gland are most commonly effected.  When the gene is not functioning properly, the protein is unable to keep the cells from dividing too rapidly, causing the increased cancer risk.   This condition is inherited in an autosomal dominant manner, meaning each first degree relative (parent, child, and sibling) of an individual with this condition has a 50% chance of inheriting the disease causing mutation.

 

Resources

https://ghr.nlm.nih.gov/condition/multiple-endocrine-neoplasia#inheritance