BRCA1 and BRCA2 genes- HBOC

Hereditary Breast and Ovarian Cancer (HBOC) syndrome

Of the 5-10% of breast and ovarian cancer that is caused by an inherited mutation in a single gene, most cases are due to a mutation in the BRCA1 or BRCA2 genes. A mutation in one of these genes impairs DNA repair and thus increases an individual's probability of developing certain cancers. The cancers most commonly seen in individuals with a BRCA1 or BRCA2 mutation are female breast cancer (50-85% lifetime risk) and ovarian cancer (20-40% lifetime risk). Other cancers are also seen more frequently in people with a BRCA mutation, including male breast cancer (6-9% lifetime risk), prostate cancer, melanoma (with a BRCA2 mutation), and pancreatic cancer. Although a mutation in BRCA1 or BRCA2 increases the chances of developing cancer, there are individuals who inherit a mutation in one of these genes and never develop cancer. Cancer predisposition caused by a mutation in BRCA1 or BRCA2 is inherited in an autosomal dominant manner, meaning each first degree relative (parent, child, and sibling) of an individual with this condition has a 50% chance of inheriting the disease causing mutation.

To learn more about HBOC visit our HBOC Kintalk group at http://kintalk.org/group/hboc 

For resources please go to Kintalk's HBOC resource list or click on this link http://kintalk.org/useful-resources-hboc/