The BARD1 gene is involved in the Fanconi anemia (FA)–BRCA pathway, which works with other important genes and is critical for DNA repair. Mutations in these genes are estimated to increase a person’s lifetime risk for breast cancer by 4 fold. Current studies are looking to see if there is a link to an increased risk of ovarian cancer as well.
No national guidelines exist for managing cancer risk in people who inherit a mutation in BARD1. We recommend consulting with a genetics expert who can assess your personal and family history of cancer, and can help you to determine the best risk-management plan.
Genetics Home Reference http://ghr.nlm.nih.gov/gene/BARD1